Ryan McPartlin graduated from the University of Illinois at Urbana-Champaign, with a degree in speech communication. During his years there he played for the Illinois Fighting Illini football team. He decided to pursue an acting career after spending time in Australia and New Zealand.
After getting a start as a model, McPartlin made his on-screen debut as a bit player during an episode of The Nanny. His first major role was in the daytime soap Passions, taking over from Dalton James as Hank Bennett from 2001 to 2004.
In 2005, McPartlin reunited with Fran Drescher in the comedy series Living with Fran, where he played her character's much younger boyfriend. Shortly after the program was cancelled, he unsuccessfully auditioned for the title role in the film Superman Returns. In 2007, he took a recurring role on NBC's Chuck, appearing as Devon "Captain Awesome" Woodcomb: he was promoted to a series regular in the second season.
McPartlin is currently married with actress Danielle Kirlin, with whom he has two sons.
2007-2011: Chuck (TV series) - Devon 'Captain Awesome' Woodcomb/Devon Woodcomb
2011: Friends with Benefits (TV series) - Evan Macklam
2010: A Clutch Powers 4D Adventure (short) - Clutch Powers
2010: Lego: The Adventures of Clutch Powers - Clutch Powers (voice)
2009: Super Capers - Will Powers
2009: Everything She Ever Wanted (TV mini-series) - Tom Allanson
2008: Mad Men (TV series) - Gentleman
2008: Swingtown (TV series) - Luke
2005-2007: Living with Fran (TV series) - Riley Douglas Martin/Riley Martin
2007: Notes from the Underbelly (TV series) - Hunter
2007: CSI: NY (TV series) - Terry Rockwell
2006: Underfunded (TV movie)
2006: The Shadow Effect (short) - Chaz Martini
2006: Pepper Dennis (TV series) - Grady Harper
2006: Model Family (TV short) - Jake
2005: What I Like About You (TV series) - Riley Martin
2001-2004: Passions (TV series) - Hank Bennett
2004: North Shore (TV series) - William
2004: Still Standing (TV series) - Jeremy
2003: According to Jim (TV series) - Bob
2003: King of the Ants - Straff
2001: Three Sisters (TV series) - Brad
2000: S Club 7 in L.A. (TV series) - Ryan
1999: Odd Man Out (TV series)
1999: The Nanny (TV series) - Performer #3