My favorite is the third season's "Fools For Love", soley because it is the first in the six-episode Tritter arc, where we see House's nemesis, played by the fabulous actor David Morse, introduced in a very embarrassing way. He causes House so much deserved trouble that the actor actually got death threats. And that first scene was so powerful that it began a lot of slash fanfic. I can only hope that Tritter/Morse reappears sometime when the writers find an equally appropriate and compelling way to do so.