Clark Duke is a native of Glenwood, Arkansas. He co-created the web comedy show Clark and Michael with his partner, Arrested Development star Michael Cera. The show was later picked up by CBS and turned into a television series. Their website features around ten episodes, featuring the two in a mockumentary following their ambitions in selling a pilot episode to a network.
In 1992, Duke was nominated for a Young Artist Award for his work on the sitcom Hearts Afire, and has also appeared in a number of other shows. After his work in 1992 to 1994 for Hearts Afire, Clark Duke landed a part in the series CSI: Crime Scene Investigation. He portrayed a fraternity member in the episode “What’s Eating Gilbert Grissom.” He followed this up with a role in Campus Ladies, before he appeared in the comedy film Superbad. Portraying a party teenager on the film, Duke was able to work with best friend Michael Cera, and actors Jonah Hill, Seth Rogen, Bill Hader, Christopher Mintz-Plasse, Emma Stone and Martha MacIsaac.
Moving on from the teen comedy flick, Clark Duke joined the cast of the ABC Family series Greek, where he played Dale for four seasons. In 2008, he was given a starring role in the comedy Sex Drive, co-written and directed by Sean Anders. He has also signed on to work on the films Kick-Ass and A Thousand Words.
In 2012, Duke joined the cast of The Office for its ninth and final season.