Actress Athena Karkanis got her start in acting in the early 2000s. She made her acting debut in an episode of 1-800-Missing, which aired in 2005; two years prior to that, however, her voice was used in an episode of the sketch show Chappelle’s Show. Her early acting credits also include episodes of Kevin Hill and Kojak. Her first regular television role was in the teen drama The Best Years, which premiered in 2007. She played the role of Dawn Vargaz, a celebrity since her infancy who enters Charles University to get a break from her celebrity life.
Karkanis is also an accomplish voice talent. She had a regular role in the animated series Growing Up Creepie, where she voiced the title character—a preteen abandoned as a baby on the doorstep of an abandoned mansion and ends up being raised by bugs. She also voiced a supporting character in the computer-animated series Skyland, doing the character Diwan. She has recently made the foray into film, making her debut in the horror flick Saw IV, which was released in 2007.