As time runs out for Dean (Jensen Ackles), Sam (Jared Padalecki) convinces him to head to Eerie, Pennsylvania to investigate a possible zombie case. Instead, they discover Doc Benton (guest star Billy Drago), a real-life doctor who, in 1816, abandoned his medical practice to follow his obsession with finding the key to eternal life by drugging people and stealing their vital organs. Meanwhile, Bobby (Jim Beaver) finds out where Bela (Lauren Cohan) is hiding, and Dean heads out to confront her, leaving Sam behind to deal with the good doctor. Dean and Bela battle it out for the last time, and Dean leaves Bela in a desperate, and possibly fatal, position. Charles Beeson directed the episode written by Sera Gamble. Source

Previously on Supernatural: A crocotta played a mean trick on Dean, making him think he got a call from his Dead Dad John with insider tips on how to get out of his deal. It was a hoax, and time continues to run out as Sam and Dean desperately search for a way out.In the appropriately named Erie, Pennsylvania, some hot shot plastic surgeon is shoved in his car trunk. Later we see the surgeon return to the hospital, severely injured. He opens his jacket to a nurse who‘s “seen everything,” and she screams in horror when his insides spill out of him.
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