Since 1999, the detectives of the Special Victims Unit in the NYPD’s 16th Precinct has been chasing those who commit sexually based offenses. The show hits a milestone this week with its 300th episode. Along the way, they’ve also brought on memorable guest stars to tell the stories. Here’s a look back on several of them. Law & Order: SVU airs Wednesdays at 9pm on NBC.


Sara Ramierez

Sara Ramierez

She’s been on SVU twice — in season two’s “Baby Killer,” she played the mother of a boy who is a murder suspect. In season four’s “Chameleon,” she was a prostitute who helped detectives investigate another prostitute’s death.


Hayden Panettiere

Hayden Panettiere

Just 11 during her memorable first role back in season two’s “Abuse,” she went from sweet and innocent child to disturbing. Then in season six’s “Escape”, her character murders her best friend to cover up her own secret sex tape.


Mark-Paul Gosselaar and Elizabeth Banks

Elizabeth Banks

As a married couple in the season three episode “Sacrifice,” they appeared in porn in order pay for their daughter’s medical bills. But when their porn producer would up dead, who killed him — and why?


John Ritter

John Ritter

In season three’s “Monogamy”, he played the husband and also the suspect of a woman whose unborn baby was taken through a primitive cesarean section.


Michael Pitt

Michael Pitt

He guest starred in season three, “Prodigy,” as a sociopath who decapitated animals as a hobby and became a suspect after an animals rights activist was murdered.


Henry Winkler

Henry Winkler

In the season three episode “Greed,” he was a grieving husband who found his wife raped and murdered or was he the actual killer?


Frank Langella, Ian Somerhalder and Jason Ritter

Frank Langella

Ian Somerhalder

Langella gave a stirring and heartbreaking performance as the father of two sons, played by Somerhalder and Ritter, in season four’s “Dominance.”


Fred Savage

Fred Savage

As a rape suspect in the season four episode “Futility,” Savage’s character defended himself, causing trouble for the prosecution.


Abigail Breslin and Lea Thompson

Abigail Breslin

In season six, “Birthright,” Breslin was a 6-year-old girl caught in a custody fight between her biological mother and her birth mother, played by Thompson.


Amanda Seyfried

Amanda Seyfried

She portrayed a teenager in season six, “Outcry,” who claimed to have been raped by three students but her story started to unravel and she eventually took back her story.


Kyle MacLachlan

Kyle MacLachlan

He played a grieving father in the season six episode “Conscience,” who killed a sociopathic child who murdered his son after finding out the child would get out of jail at 18, leaving him free to kill again.


Martin Short

Martin Short

The comedian in the season six episode “Pure,” played a character who claimed to be a psychic — but was actually a twisted serial virgin rapist.  


Alfred Molina, Angela Lansbury and Bradley Cooper

Bradley Cooper

Angela Lansbury

These three guest starred in season six, “Night,” and also the Law and Order: Trial by Jury crossover episode “Day.” Molina played a computer programmer with Asperger’s Syndrome who was accused in the rapes of illegal immigrants. Lansbury was the overprotective mother and Cooper, the sleazy family attorney.   Dean Cain
As a surgeon who controlled the women in his life in the season seven episode “Starved,” he fought to unplug the feeding tube of his wife after she committed suicide.


Ludacris

Ludacris

He portrayed Finn’s trouble making nephew in season seven, “Venom.” When he later went on trial in season eight, “Screwed,” he dug up dirt on all the detectives, which he used against them– and succeeded.  


Brittany Snow

Brittany Snow

She played a bipolar girl in the season seven episode “Influence” who accused two classmates of rape and killed someone in a car crash after attempting suicide.


Jerry Lewis

Jerry Lewis

He was unrecognizable in a dramatic but memorable performance in season eight, “Uncle,” as a homeless man brought in for questioning in the latest rape and murder who actually turned out to be Munch’s uncle with dementia.  


Elle Fanning

Elle Fanning

She played a troubled foster child in season eight, “Cage,” who tried to murder Detective Beck and also tried to commit suicide.  


Bob Saget

Bob Saget

In the season eight episode “Choreographed,” he took on the role of a husband who wasn’t all that he seemed after a friend wound up dead.  


Blair Underwood

Blair Underwood

He played a former drug addict whose wife accused him of rape in the season eight episode “Burned.” The detectives didn’t know who to believe.  


Cynthia Nixon

Cynthia Nixon

She brilliantly portrayed a woman in season nine, “Alternate,” as someone with four alternate personalities that in the end was all an elaborate act.  


Melissa Joan Hart

Melissa Joan Hart

Playing a high school teacher in season nine, “Impulsive,” she was accused of statutory rape after one of her students got gonorrhea. But the student turned out to be a sex addict who confessed to raping her.  


Robin Williams

Robin Williams

In the 200th episode of the series, season nine’s “Authority,” Williams’ portrayal of a killer who defied authority earned him an Emmy nomination.  


Julie Bowen and Luke Perry

Luke Perry

The two played foster parents accused of bribing their son to do abusive medical testing in the season 10 episode, “Trials.”  


Ellen Burstyn

Ellen Burstyn

Her Emmy-winning role in the season 10 episode “Swing” saw her as Elliott’s estranged, bipolar mother.  


James Brolin

James Brolin

As Stabler’s old mentor who helped the detectives in the season 10 episode “Lunacy,” suspicion soon fell on him in the death of a famous astronaut.  


Carol Burnett and Matthew Lillard

Carol Burnett

Both were riveting as she played a former Rockette and he was her nephew helping a murder investigation in season 10 “Ballerina.” But the suspicion soon fell on them instead.  


Eric McCormack

Eric McCormack

He portrayed the CEO of a dating website in season 11 “Sugar” who had emotionally abused and neglected his daughter for years.  


Scott Foley

Scott Foley

In the season 11 episode “Hammered,” his character couldn’t remember the events of the night before after waking up with a dead woman in his bed.  


Kathy Griffin

Kathy Griffin

As a lesbian activist in season 11, “P.C.,” members of her rights group started getting attacked, and she soon became a target as well.  


Mischa Barton

Mischa Barton

She played a prostitute in season 11, “Savior,” who turned to Olivia for help.  


Jennifer Love Hewitt

Jennifer Love Hewitt

Her character in season 12, “Behave,” said the same man raped her for 15 years and she lived in terror but then recanted her story.  


Marcia Gay Harden

Marcia Gay Harden

As an FBI agent in the season 12 episode “Penetration,” she guest starred as a rape victim who refused help because she thought she’d be taken off her latest undercover assignment.  


Debra Messing

Debra Messing

In the season 12 episode “Pursuit,” she was a no-nonsense TV journalist bringing down child predators but started receiving threats of her own.  


John Stamos

John Stamos

He played the charming businessman who also was grossly creepy, as he liked impregnating women -fathering 47 kids- in season 12 “Bang”.  


Rita Wilson

Rita Wilson

She guest starred in the season 12 episode “Delinquent” as the distraught mother of a twisted teen who claimed Stabler abused him while in custody.

(images courtesy of NBC)

Esther Gim

Contributing Writer, BuddyTV