Norman Reedus began his career as a model, appearing in campaign for Prada and Durban, among others. He made his acting debut in the late 1990s, and made his major break alongside Willem Dafoe in the 1999 film The Boondock Saints. He later reprised his role in the film's sequel, released in 2009.
Reedus also starred in films such as Blade II, The Notorious Bettie Page and American Gangster. He is also known for his role in the AMC zombie series The Walking Dead. He has also directed several short films.