Grey’s Anatomy returns for season 22 on ABC Thursday, with the premiere set for October 9, 2025, at 10 p.m. ET/PT. New episodes roll out weekly, with next-day streaming on Hulu in the U.S. and a free, limited catch-up window in Canada on CTV. In the U.K. and Australia, episodes arrive weekly on Disney+ beginning October 10 (U.K.) and October 11 (Australia). The season opens in the immediate aftermath of the Grey Sloan Memorial gas explosion, with fallout that extends into episode two.
Release date & how to watch
The Thursday night anchor remains unchanged: ABC carries the premiere on October 9 at 10 p.m. ET/PT, with episodes streaming in the U.S. on Hulu the following day, starting Friday, October 10. Canada airs episodes at 10 p.m. ET/PT on October 9, then offers about seven days of free catch-up via CTV’s site and app. The U.K. gets weekly episodes on Disney+ from Friday, October 10, and Australia gets weekly drops on Disney+ from Saturday, October 11.
- U.S.: ABC Thursdays 10 p.m. ET/PT; Hulu next day (Friday).
- Canada: CTV Thursdays 10 p.m. ET/PT; free streaming window (~7 days) on CTV online/app.
- U.K.: Disney+ weekly from Friday, October 10.
- Australia: Disney+ weekly from Saturday, October 11.
Viewers can also leverage a Hulu 30-day free trial in the U.S., while Canada’s CTV posts each episode online for a limited free window after broadcast.
Cast & characters (complete list from the sources)
The returning season 22 ensemble features:
- Ellen Pompeo — Dr. Meredith Grey
- Chandra Wilson — Dr. Miranda Bailey
- James Pickens Jr. — Dr. Richard Webber
- Kevin McKidd — Dr. Owen Hunt
- Caterina Scorsone — Dr. Amelia Shepherd
- Camilla Luddington — Dr. Jo Wilson
- Jason George — Dr. Ben Warren
- Kim Raver — Dr. Teddy Altman
- Chris Carmack — Dr. Atticus “Link” Lincoln
- Anthony Hill — Dr. Winston Ndugu
- Alexis Floyd — Dr. Simone Griffith
- Harry Shum Jr. — Dr. Benson “Blue” Kwan
- Adelaide Kane — Dr. Jules Millin
- Niko Terho — Dr. Lucas Adams
Recurring and guest players highlighted ahead of the premiere include:
- Debbie Allan — Dr. Catherine Fox
- Scott Speedman — Dr. Nick Marsh
- Jaicy Elliot — Dr. Taryn Helm
- Floriana Lima — Nora Young
- Trevor Jackson — Dr. Wes Bryant
- Jade Pettyjohn — guest appearance
- Curtis Edward Jackson — guest appearance
- Micah McNeil — security guard (first-look still)
There are notable exits: Jake Borelli (Dr. Levi Schmitt) and Midori Francis (Mika Yasuda) have departed their primary roles.
Premiere setup: fallout from the Grey Sloan explosion
Season 22 “reveals the full and tragic extent of the Grey Sloan explosion.” The finale’s acetylene tank blast tore through the operating rooms and left loved ones and colleagues in harm’s way. Going into the premiere, the narrative stakes expressly include Miranda (Chandra Wilson), Link (Chris Carmack), and Ben (Jason George), with a sobering reminder that a major loss is possible as the two-part crisis unfolds.
What the creatives are saying
Showrunner Meg Marinis praised newcomer Trevor Jackson and teased how his character changes the intern dynamic: “He’s so talented. It’s been so fun with him on set already, and he is definitely mixing up the dynamics between our resident cast members, specifically Simone and Lucas.”
Grey’s Anatomy returns for season 22 on ABC Thursday — schedule snapshot
The weekly placement is unchanged: Thursdays at 10 p.m. ET/PT on ABC all fall, with Friday becoming the key next-day streaming drop on Hulu for U.S. viewers. In Canada, the Thursday broadcast is followed by a roughly week-long free catch-up window on CTV’s site and app. The U.K. and Australia are both on Disney+ with weekly releases beginning October 10 and October 11, respectively.
Why this cast mix matters
Exits for Jake Borelli and Midori Francis reshape the intern storylines, while Trevor Jackson’s Dr. Wes Bryant adds fresh pressure points for Simone (Alexis Floyd) and Lucas (Niko Terho). At the same time, legacy anchors remain in place, led by Ellen Pompeo as Meredith Grey alongside Chandra Wilson and James Pickens Jr. That balance should keep the long-running tone intact even as the post-explosion arc forces hard choices across the opening hours.
When and where to stream each week
Mark Thursdays for ABC live viewing and Fridays for U.S. streaming on Hulu. Canadian viewers can catch up for free via CTV’s digital platforms for about a week after each airing. Weekly international releases land on Disney+ in the U.K. on Fridays and in Australia on Saturdays, starting October 10 and October 11.
The bottom line
Grey’s Anatomy season 22 is back on ABC at 10 p.m. ET/PT, with the premiere set for Thursday, October 9. The cast list stays deep and familiar while absorbing key changes, and the two-episode crisis that follows the Grey Sloan explosion sets a high-stakes tone. If you’re asking “how to watch,” the path is simple: ABC on Thursday, Hulu on Friday, CTV’s free window in Canada, and weekly Disney+ drops in the U.K. and Australia. Longtime viewers get stability with Ellen Pompeo, Chandra Wilson, and James Pickens Jr.—plus a jolt from Trevor Jackson and the reshuffled intern ranks—to carry them into the fall.
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