The latest General Hospital spoilers for Friday, September 5, 2025, promise a whirlwind of drama, shocking revelations, and dangerous showdowns. The new General Hospital spoilers video preview teases intense confrontations across Port Charles and beyond, as everyone scrambles to cover their tracks in the aftermath of Drew Cain’s shooting.

Who Shot Drew Cain?

The mystery of who pulled the trigger on Drew has consumed Port Charles. Diane is seen asking Sonny which of his associates she should prepare to defend, underscoring the long list of suspects tied to him. Among them are Carly, Alexis, and even Sonny’s own son, Michael. Tracy claims she spotted Michael outside Drew’s when the shots rang out, raising questions about whether he’s the culprit.

Meanwhile, Alexis is in the hot seat for another reason. Kristina confronts her, insisting it would be disastrous to bring Scout into her home. Alexis may be the girl’s grandmother, but she’s also hiding Ric in her basement—a secret that could have dire consequences if exposed.

Alibis, Lies, and New Suspicions

Inside General Hospital, Portia and Nina share tense words about the shooting. Drew’s influence has haunted both women, and suspicion lingers around them. While Portia may have Isaiah to back her up as an alibi, Nina’s credibility is shakier. She reportedly lied to make Willow serve as her alibi, leaving many wondering if she’s hiding something bigger.

Elsewhere, Lulu taps into her reporter instincts, pressing Willow with pointed questions. Whether Willow will reveal key details that could crack the case remains to be seen.

High Stakes in Croatia

Far from Port Charles, at the Five Poppies resort in Croatia, the danger is just as high. Vaughn and Josslyn are shown tied back-to-back, their undercover mission as newlyweds spiraling out of control. Josslyn questions Vaughn’s willingness to sacrifice himself for her, hinting at a bond that has deepened under fire. Are sparks flying between them, or is survival the only thing keeping them together?

Anna, meanwhile, corners Brennan once again. She reminds him that he owes her and suggests she will soon collect, possibly pushing him to help solve Drew’s shooting. Her leverage—threatening to expose his dealings to Carly—could make Brennan a wild card in this tangled mystery.

Jason’s Return and a Deadly Cliffhanger

The video preview ends with a heart-stopping moment: a gun goes off as Jason narrowly avoids being hit. His sudden return to the Five Poppies could mean salvation for Josslyn, Vaughn, and Britt, but only if he can outmaneuver the threat closing in. Will Jason’s timing be enough to prevent another tragedy?

Related: ‘General Hospital’ Spoilers: Drew’s Shooting Sends Shockwaves Through Port Charles

As the week wraps up, viewers are left with more questions than answers. Who really shot Drew Cain? Which alibis will hold up under pressure? And can Jason protect his loved ones before it’s too late? Friday’s episode is shaping up to be a must-watch for fans of General Hospital.

 

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