Days of Our Lives (Peacock) heads into Friday, November 21, 2025, with a charged slate that puts EJ DiMera’s secret science front and center and sets up a very public clash in the hospital halls. These Days of Our Lives spoilers dig into the photos and episode teases for November 21, with specifics on EJ, Dr. Rolf, Mark, Rachel, Brady, Sarah, Kayla, Susan, Aaron, and Sophia.

What happens on November 21 (Friday)

  • Kayla becomes suspicious of EJ. Kayla Brady (Mary Beth Evans) starts connecting dots after a run-in with Mark (Jonah Robinson), zeroing in on EJ DiMera’s (Dan Feuerriegel) latest scheme.
  • Dr. Rolf and Mark get to work in EJ’s lab. Dr. Wilhelm Rolf (Richard Wharton) and Mark roll up their sleeves on a “mysterious experiment” tied to EJ’s plans.
  • Rachel confronts Brady and Sarah. After catching a hug at University Hospital, Rachel Black (Alice Halsey) goes off on Brady Black (Eric Martsolf) and Sarah Horton (Linsey Godfrey).
  • Susan has words for EJ. Susan Banks (Stacy Haiduk) steps in with pointed motherly “questions” that threaten to rattle EJ’s cool.
  • Aaron tries to reach Sophia. Aaron reaches out as Sophia (Rachel Boyd) returns, adding another emotional thread to the day.

Why EJ’s “mystery experiment” matters

Photos tease lab action as Mark and Dr. Rolf fire up equipment under EJ’s orders. With Kayla sniffing around and Susan pressing EJ directly, Friday looks like the moment when the lab story stops simmering and starts to boil. If that experiment ties to any DiMera endgame, expect fallout to hit multiple families fast.

Hospital tension: Rachel, Brady & Sarah

Rachel’s anger isn’t quiet. After spotting Brady and Sarah embracing, she confronts both in a very public scene. That reaction also stirs up Xander’s insecurities off-screen this week, as questions swirl about whether Brady has drawn a hard line with Sarah or if the bond between them is growing.

Legal moves spill into Friday

Justin Kiriakis is busy on multiple fronts around November 20–21, representing Jennifer Horton in a custody dispute and Sarah in her divorce from Xander Cook. Those cases loom over Friday’s tensions, even as Salem’s focus shifts to the lab and the hospital showdown.

Cast & characters appearing in these Days of Our Lives spoilers

  • EJ DiMera — played by Dan Feuerriegel
  • Dr. Wilhelm Rolf — played by Richard Wharton
  • Mark — played by Jonah Robinson
  • Kayla Brady — played by Mary Beth Evans
  • Susan Banks — played by Stacy Haiduk
  • Brady Black — played by Eric Martsolf
  • Sarah Horton — played by Linsey Godfrey
  • Rachel Black — played by Alice Halsey
  • Sophia — played by Rachel Boyd
  • Aaron — appearing in outreach scenes with Sophia

What to watch for next

EJ’s secrecy plus Rolf in a lab usually signals DiMera-grade chaos. Kayla’s suspicions could get traction fast if she finds a medical paper trail or odd supply orders. At the hospital, Rachel’s public call‑out of Brady and Sarah raises real questions about boundaries and trust—especially with Sarah’s divorce and Xander’s jealousy in play. Keep an eye on whether Friday plants the clue that finally exposes EJ’s project.

Related: ‘Days of Our Lives’ Spoilers: Nov. 17–21 Chaos, Confrontations & Rachel’s New Target

Days of Our Lives streams on Peacock. Check back after airtime on November 21, 2025, for updates and recaps of the developments above.

Bottom line: These days of our lives spoilers for November 21 point to EJ’s lab heating up and a Rachel‑Brady‑Sarah confrontation that won’t be easy to walk back.

 
 
 
 
 
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