Life is Wild follows Katie Clarke and her family as they are moved from New York City by her veterinarian father, Danny, to South Africa, together with her brother Chase, Danny's second wife Jo, along with Jo's rebellious teenage son Jesse and seven year old daughter, Mia. The family is to live in a broken-down lodge, The Blue Antelope, in a game reserve, where Danny's deceased first wife grew up. Danny tries to keep his troubled family together while making a difference in the people and animals of South Africa.