Some cases just end tragically, no matter what the BAU does. Such is the case with Criminal Minds
season 11 episode 14, "Hostage."
Gina escapes from the UnSub 10 years after he took her, and while she brings the police back to his house, where another girl, Sheila, is sick, the UnSub, Thompson, gets away with a third girl, Violet. Sheila dies in the hospital due to her injuries, and her mother is the one who makes the final move of the hour, shooting Thompson as Hotch and Rossi are taking him out of the hospital.
Here are the reasons why Thompson probably had that coming in "Hostage."