Scott Krinsky graduated from Salisbury University in Maryland with degrees in communication and broadcast journalism. However, he pursued a career in stand-up comedy, having performed in several venues in Los Angeles.
Krinsky has appeared on screen as early as 1994, through an uncredited role in the Nick Nolte film I'll Do Anything. His first credited role came in the 2001 indie Cutting Tom Finn.
Krinsky's first major TV role came in 2006, when he snagged a recurring stint in The OC. In 2007, he joined the cast of NBC's Chuck, appearing as scheming Nerd Herd member Jeff Barnes. He was promoted to series regular from the second season.