Lori Loughlin started her career at age 12, when she worked as a model. Already a well-known face in her teens, she took her first major acting gig in 1980, when she joined the ABC soap The Edge of Night. Later that decade, she would take her first major primetime role, in the comedy series Full House; she stayed on the show until it wrapped up in 1995.
After a role in the shortlived sitcom Hudson Street, Loughlin focused on TV movies, and made her return to the big screen in 1999's Suckers. In 2004 she returned to regular television work in the drama series Summerland, for which she won a Prism Award. After a stint in another short-lived series, In Case of Emergency, she joined the cast of the CW's 90210, as Debbie Wilson. She was then cast as Diana Marshall on the 2010 TV movie Meet My Mom.
Loughlin was married twice. Her second husband is fashion designer Mossimo Giannuli, with whom she has two daughters.