Lesley-Ann Brandt was born and raised in Cape Town, South Africa but traveled to Auckland, New Zealand in 1999 with her family. She started out as a model before she got noticed by casting directors, who suggested she take up acting. She trained with various acting coaches in New Zealand and has since appeared on a number of TV commercials. This led her to be cast on several shows like Shortland Street in 2007. Two years later, she rose to fame as Leilani Fa'auigaese in the show Diplomatic Immunity.
In 2010, Lesley-Ann Brandt booked the role of Naevia on Spartacus: Blood and Sand, airing on the Starz Network. She followed it up with performances on Legend of the Seeker, The Hopes & Dreams of Gazza Snell, and even on the show Chuck. She also reprised her role on the Spartacus prequel, Spartacus: Gods of the Arena, in 2011.
2011: Spartacus: Gods of the Arena (TV series) - Naevia
2011: InSight - Valerie Khoury
2011: Chuck (TV series) - Fatima Tazi
2010: This Is Not My Life (TV series) - Hine/WAI tv field reporter
2010: The Hopes & Dreams of Gazza Snell - Sharon
2010: Legend of the Seeker (TV series) - Sister Thea
2010: Spartacus: Blood and Sand (TV series) - Naevia
2009: Diplomatic Immunity (TV series) - Leilani Fa'auigaese
2007: Shortland Street (TV series) - Sonia