Initially aspiring to become a football player, D.B. Woodside moved to acting when he was sidelined by an injury and later decided to join his school's drama club. He later graduated from the University of Albany and the Yale School of Drama.
After making his debut in the second season of Murder One, Woodside starred in films such as Scar Face and Romeo Must Die. After a recurring role in Buffy the Vampire Slayer, he joined the cast of Fox's 24, as White House chief of staff (and, in later seasons, President) Wayne Palmer. He was a regular in the third and sixth seasons, and was a guest star in the fifth.
After guest roles in shows such as Lie to Me, Hawthorne and Private Practice, Woodside took a recurring role on the CW's Hellcats, as doctor Derrick Altman.
- Scar City (1998)
- Romeo Must Die (2000)
- More Dogs Than Bones (2000)
- Something More (2003)
- Easy (2003)
- First. (2007)
- Mississippi Damned (2009)
- Murder One (regular, 1996-1997)
- The Division (regular, 2001)
- Once and Again (recurring, 2002)
- Buffy the Vampire Slayer (recurring, 2002-2003)
- 24 (regular, 2003-2007)
- Hawthorne (recurring, 2009)
- Monk (recurring, 2009)
- Hellcats (recurring, 2010-present)