What a Difference a Day Makes

Season 5, Episode 22 -  Air Date: 5/7/2009
6 Ratings


As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experience...

Grey‘s Anatomy: Episode 5.22 "What a Difference a Day Makes" Recap (Page 1/4)

The 100th episode of Grey‘s Anatomy opens with an Izzie (Katherine Heigl) voiceover, except, it‘s not really a voiceover because we see her in her hospital bed, wearing a scarf on her head, whispering her monologue to someone we can‘t see. She looks very weary and cancery, and she‘s talking about big days. The days that start out normal but end big are the biggest kinds of days. While she talks, Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) are at the church where they will be getting married at the end of the day. That‘s how their day will end, but they are starting the day by going to work, because if we have learned nothing about these people, it is that they are workaholics.
Read more »