"the personal cost of the apocolypse for our boys is real, they will suffer in every possible way," reveals Sera Gamble. Sam, Dean and Cas continue their hunt for the elusive God, Lucifer (Mark Pelligrino) will return to bedevil Sam and we will finally meet the arc angel Michael despite his lack of body (It seems only Dean can be his human host!)But its not all Doom and gloom as Sam and Dean get involved in some'deliciously hoary horror' in several stand alone episodes! (Source TV Guide)

Ausiello: The show’s 100th episode (slated to air in March or April) will be a big one for Jensen Ackles. To find out why, pick up the new issue of Entertainment Weekly, on sale Friday

5.14-Dead men dont wear plaid-casting call SHERIFF MILLS] In her mid 30s to mid 40s, tough and no-nonsense while on the job, but tender and loving toward her family, she's the Sheriff in a small town, she’s calm under pressure even when things turn very personal...please submit all ethnicities...GUEST STAR (5) [KAREN SINGER] In her late 20s to 30s. Blonde, young and attractive, she’s wise, direct, a straight shooter and nobody’s fool...GUEST STAR (16)

Episode 5.11: Sam, Interrupted Airdate: January 2010 10/18 - Martin Creaser: A weathered man in his late 40s-mid 50s, this twitchy, anxious ball of nerves is a former hunter who has ended up in a psych ward, where strange happenings are afoot. Any ethnicity. Dr. Erica Fletcher: A beautiful, smart, credible psychiatrist in her 30s with a sweetly sympathetic manner who seems to understand Dean's conflict and pains. Any ethnicity. Source: SpoilerTV

Episode 5.12: Swap Meat Airdate: January 2010 11/01 - Sam and Dean switch bodies in episode 12! Source: The Ausiello Files 11/01 - Gary: 17 years old (would prefer 18 and overs), puny, gawky, bespectacled, smart and geek (think "McLovin" from "Superbad"), he's a naive, amateur Satanist who works at a fast food joint and longs to break free from his wealthy, stifling parents. He's granted one of his wishes, and starts to live the life he's always wanted. Nora: 16 years old (would prefer 18 and over), she is a cute, smart, alternative girl (in the vein of Thora Birch in "American Beauty") who is a naive, conflicted high school student, she's an amateur Satanist, she's not really interested in hurting anyone; she's mostly going along with Gary and Trevor's plot because she has a crush on Gary. Nora's follower-type nature is squelched when she becomes possessed by a dark force. Please submit all ethnicities. Source: SpoilerTV

[“Sam, Interrupted,” airing January 14], the boys are contacted by a hunter who had worked a case that was so traumatic that he went crazy. He’s been voluntarily living in an insane asylum and something not right is happening there, and he calls the boys. So Sam and Dean check themselves in. The challenge of an episode like this is that it’s well-trodden territory in horror movies and television shows, so we made sure we had a different take. You don’t have to be crazy to be a hunter, but it helps. That’s what Sam and Dean explore. We’re also doing our twist on a zombie story. It’s different from the Croatoan virus zombies. These are post-modern with lots of personality.

Will we finally see God? Sera Gamble says :Not any time soon, but people are definitely looking for him. It’s an ongoing quest for Castiel [Misha Collins]. It’s vitally important for him and increasingly interesting for the boys. Historically Sam has more faith. The jury is out for Dean as to whether or not God currently exists. We might be the only show on the CW actively searching for God.

Has God been cast yet? Misha Collins told me it would be cool if it were Miley Cyrus. [Laughs] I can’t tell you anything about God. What’s Lucifer’s next move? You’ll be seeing more of Lucifer. I really dig the actor [Mark Pellegrino]. You’ll learn more about how his taking Sam over figures into his plans. And how he came to find Nick, who’s his current [host]. And you will definitely start to understand the Archangel Michael’s perspective. He’s trying to become embodied and Dean is the only possible vessel for him. He’s not walking around in the here and now, so we have to be creative in introducing Michael. You will meet him. Are there any holiday deconstructions this year, like you’ve done with the pagan roots of Christmas and Halloween? We will be doing a very dark and sinister Valentine’s Day episode. It’s an exploration of the nature of love and desire, which can be very destructive. Anything else you can share? We’re also doing a body swap episode, Sam with a human—