The next time Castiel appears, Dean asks why Sam wasn't allowed to get in on this Back to the Future action.  Castiel explains that Dean has to do this alone, and also reminds him that if he alters the future and never becomes a hunter, all the people he's saved will die.  Dean cares about the lives of strangers, but he's not going to let his parents die again.  This is all very reminiscent of "What Is and What Should Never Be," is it not?

While Dean (Jensen Ackles) steals the Colt from a guy's safe in Colorado, Mary discovers that the demon is currently hanging out at her friend's house.  She rushes over to jump in the fray along with Grandpa Sam, but his shotgun is no match for the Yellow-Eyed Demon, who's been posing as a friendly doctor and collecting some souls.  Mary bursts in, stabs Yellow Eyes and kicks his ass a bit, but is soon overpowered by him.  The demon immediately takes a shine to her, which may be one reason why he comes back to visit 10 years down the line.  Dean arrives to save the day before things can get ugly, but the demon smoke jumps out of the doctor and takes off.

Dean tells Samuel that they have to kill the demon to save Mary's life.  He then explains that Mary is his mother and that she's destined to be killed in 1983 if they don't do something.  Grandpa Sam thinks he's pretty crazy, but Dean is persuasive and convinces him that it's time to send Yellow Eyes back to Hell.  When Sam tries to get his hands on the Colt, Dean realizes that the pesky demon has possessed him.  Yellow Eyes now knows what the future holds, which definitely isn't a good thing.

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