Jane Kaczmarek was born on December 21, 1955 in Milwaukee, Wisconsin. This Polish American actress attended the University of Wisconsin where she majored in theater. Her versatility as a comedian and a dramatic actress landed her countless roles on television. Her most popular exposure was from the TV series Malcolm in the Middle as Lois. Her performance in the series got her many nominations. However, she did not win any of them. Aside from this, she also appeared in Party of Five, The Practice, Cybill, Felicity, Equal Justice and Pleasantville. At present, she is part of the series Help Me, Help You as Anne. Anne was Dr. Bill Hoffman's wife. Their 25-year marriage has come to an end.