Annie Wersching was born and raised in St. Lious, Missouri, where she spent fourteen years with the St. Louis Celtic Stepdancers. For most of her youth, they toured and traveled to compete in Irish dance. She later entered Millikin University where she received a degree in musical theater. Upon graduating, she relocated to Chicago where she started touring with Anything Goes and A Christmas Carol. She then appeared in numerous stage productions and shifted to television thereafter. Wersching's first appearance on TV was on Star Trek: Enterprise where she played Liana. Her other television credits include Birds of Prey, Frasier, Angel, Charmed, E-Ring, Cold Case and Boston Legal. In 2007, she was cast as Amelia Joffe for the soap opera, General Hospital.